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MYP_002427
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Basic Information
hexarginin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiviral
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
6 amino acids
C36H74N24O7
Standard
Sequence
RRRRRR
Physicochemical Analysis
955.13 Da
12.00
5.76
5.56
0.9600
-4.50
0.48
-2.53
485.67
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
580.22
-7.60
25.0
13.0
35.0
67.0
0.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0347368 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0356658 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: Daunorubicine
Bio-Activity Profile
Anticancer
HL-60
PaperSynthesis of daunomycin-oligoarginine conjugates and their effect on human leukemia cells (HL-60) Evidence URLhttps://doi.org/10.3998/ark.5550190.0009.313
RECORD: Rec_0387392 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Labelled with fluorescein with aminohexanoic space
None
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0402409 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Amidation
Bio-Activity Profile
Antimicrobial Antimycobacterial Immunomodulatory
Mycobacterium smegmatis RIF-susceptible
125 μg/mL
MIC
PMID24411680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24411680/
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