Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length454 amino acids

Chemical FormulaC2275H3547N597O661S26

DescriptionStandard

        MAMHAPPTPYDPVTKHWDSYMLRFDCFLEANDRKKNMFLRYCGWEVFDTAKDLSELTPLQSVAWSVLQQMLRTHYASKPSKHICRHEFNIRNQKKYESINAYVAALPRPGFLHDINHFGCNPCLRLISEDLISEQKGSSSLMPLLCCLSLPPPTVTANIDRTSSIDYSLVGPPVATSDCVDLDLKGEFFSNVHRSPAPFPPPPLSFPVDQERMVQFGISTYFFNTAGDVYYKAGALTFWMVDEMVPQEIKIRLNTSSFQPFIPQLKTLYPNLAMKLKLSPSSAPSLSIAPESLSLAASVDIQAFAILPNSSLAPLFLIGVSSPVSAQVSVNSTRISGSLKLGRLKFSLKHSDVGVFSVQMLEYLINFLTTSILIPQMNGKDITGSYIQQAEHMVDKPCESCFSQRLIERDCAAVRLLLPNAETRQGETQPGMKEKFPGREDNYLEGRCSITGGF
    

Molecular Weight50670.79 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.70

Net Charge (pH 7.4) -1.70

Charge Density (pH 7.0) -0.0015

GRAVY Index-0.12

Hydrophobic Moment 0.66

Boman Index0.07

Instability Index47.88

Aliphatic Index 84.85

Aromaticity 0.0947

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0055751 VERIFIED: NO

Provenance & Taxonomy

OrganismThamnophis sirtalis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria