Peptide Database

Peptide NameAntimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC84H145N21O23

DescriptionStandard

        GFLGSLLKTGLKVGSNLL
    

Molecular Weight1817.18 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.0977

GRAVY Index0.81

Hydrophobic Moment 0.57

Boman Index0.35

Instability Index-14.14

Aliphatic Index 146.11

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 713.84

LogP -6.16

H-bond Donors 25.0

H-bond Acceptors 25.0

Rotatable Bonds 63.0

Heavy Atoms 128.0

Ring Count 1.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0370032 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetPseudomonas aeruginosa 0380972

Activity60 μM

MethodMIC

RECORD: Rec_0376506 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStaphylococcus aureus (MRSA)

Activity7 μM

MethodMIC

RECORD: Rec_0387630 VERIFIED: YES

Provenance & Taxonomy

OrganismSilurana paratropicalis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

Activity25 μM

MethodMIC

RECORD: Rec_0389812 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli

Activity5 μM

MethodMIC

RECORD: Rec_0390109 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

Tax ID8364

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

MethodQualitative antimicrobial activity assay

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