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MYP_002401
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Basic Information
Antimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
18 amino acids
C84H145N21O23
Standard
Sequence
GFLGSLLKTGLKVGSNLL
Physicochemical Analysis
1817.18 Da
10.00
1.76
1.55
0.0977
0.81
0.57
0.35
-14.14
146.11
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
713.84
-6.16
25.0
25.0
63.0
128.0
1.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0264928 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
5 μM
MIC
PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
RECORD: Rec_0289482 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923 and MRSA
2.5-5 μM
MIC
PaperHost-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA).
RECORD: Rec_0304084 VERIFIED: YES
Provenance & Taxonomy
Silurana paratropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
50 μM
MIC
PMID21498136 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21498136/
RECORD: Rec_0306243 VERIFIED: YES
Provenance & Taxonomy
Silurana tropicalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0316734 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
Antimicrobial
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
PaperM.F. Ali et al. / Biochimica et Biophysica Acta 1550 (2001) 81-89. Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae) Evidence URLhttps://www.uniprot.org/uniprotkb/P84386/entry
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