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MYP_002401
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Basic Information
Antimicrobial peptide 6 (XT-6; Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
18 amino acids
C84H145N21O23
Standard
Sequence
GFLGSLLKTGLKVGSNLL
Physicochemical Analysis
1817.18 Da
10.00
1.76
1.55
0.0977
0.81
0.57
0.35
-14.14
146.11
0.0556
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
713.84
-6.16
25.0
25.0
63.0
128.0
1.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0057992 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
150 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/11738090/ PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
RECORD: Rec_0061381 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus epidermidis 1420129
3 μM
MIC
PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
RECORD: Rec_0085131 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
Antimicrobial
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
150.0 μM
HC50
PaperM.F. Ali et al. / Biochimica et Biophysica Acta 1550 (2001) 81-89. Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae) Evidence URLhttps://www.uniprot.org/uniprotkb/P84386/entry
RECORD: Rec_0096381 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli 25922
6 μM
MIC
PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
RECORD: Rec_0098785 VERIFIED: YES
Provenance & Taxonomy
Xenopus tropicalis [Animal]
8364
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Clinical isolates: Staphylococcus aureus 8325
6 μM
MIC
PMID11738090 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11738090/
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