Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 1.13 (Charybdotoxin c) (ChTx-c)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC179H287N53O57S7

DescriptionStandard

        QFTNVSCTTSKECWSVCEKLYNTSRGKCMNKKCRCYS
    

Molecular Weight4317.97 Da

Isoelectric Point (pI)9.08

Net Charge (pH 7.0)4.70

Net Charge (pH 7.4) 4.40

Charge Density (pH 7.0) 0.1270

GRAVY Index-0.76

Hydrophobic Moment 0.51

Boman Index-0.26

Instability Index50.76

Aliphatic Index 26.22

Aromaticity 0.1081

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1850.10

LogP -24.69

H-bond Donors 73.0

H-bond Acceptors 69.0

Rotatable Bonds 146.0

Heavy Atoms 296.0

Ring Count 5.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0053074 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0289269 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0332719 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetBacillus subtilis