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MYP_002382
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IEEIYKKIEEIYKKIEEIYKKIEEIYKKIEEIYKKXK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005700 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino-acid peptide with noncanonical β-alanine/lipid modification [Modified]
Acetylation
Amidation
X36 = β-alanine; Lys37 palmitoylated with C16 (palmitic acid)
Bio-Activity Profile
Antiviral
Influenza A/Puerto Rico/8/34 (H1N1)
3.15±1.79 μM
EC50
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0047712 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino-acid peptide with noncanonical β-alanine/lipid modification [Modified]
Acetylation
Amidation
X36 = β-alanine; Lys37 palmitoylated with C16 (palmitic acid)
Bio-Activity Profile
Antiviral
Huh-7 cells
>100 μM
CC50
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0086203 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
L-amino-acid peptide with noncanonical β-alanine/lipid modification [Modified]
Acetylation
Amidation
X36 = β-alanine; Lys37 palmitoylated with C16 (palmitic acid)
Bio-Activity Profile
Antiviral
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0313689 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino-acid peptide with noncanonical β-alanine/lipid modification [Modified]
Acetylation
Amidation
X36 = β-alanine; Lys37 palmitoylated with C16 (palmitic acid)
Bio-Activity Profile
Antiviral
Influenza A/Hong Kong/8/68 (H3N2)
12.9±5.55 μM
EC50
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0335544 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino-acid peptide with noncanonical β-alanine/lipid modification [Modified]
Acetylation
Amidation
X36 = β-alanine; Lys37 palmitoylated with C16 (palmitic acid)
Bio-Activity Profile
Hemolytic
MDCK cells
>100 μM
CC50
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
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