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MYP_002376
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Basic Information
MCoKKAA double mutant
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C132H217N45O46S6
Standard
Sequence
GGVCPKILAACRRDSDCPGACICRGNGYCGSGSD
Physicochemical Analysis
3362.80 Da
7.77
0.71
0.41
0.0207
-0.11
0.53
-0.02
61.78
51.76
0.0294
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1453.67
-22.59
57.0
53.0
107.0
229.0
3.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023410 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Alexa-488
Cyclization
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0041737 VERIFIED: YES
Provenance & Taxonomy
Momordica cochinchinensis [Plant]
Cyclotide/MCoTI
3674
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Fluorophore labeling
Cyclization
4-21, 11-23, 17-29
N-term detail: Lysine rsidue labeled with Alexa-488; backbone cyclization reported in source
Bio-Activity Profile
Cell-penetrating peptide
RAW 264.7; MCF-7
Fluorescence-based uptake assay
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0105825 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Alexa-488
Cyclization
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
RECORD: Rec_0178940 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Lysine rsidue labeled with Alexa-488
Cyclization
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0195368 VERIFIED: YES
Provenance & Taxonomy
Protein derived [Animal]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Alexa-488
Cyclization
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID21873420 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21873420/
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