Peptide Database

Peptide NameMCoKKAA double mutant

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC132H217N45O46S6

DescriptionStandard

        GGVCPKILAACRRDSDCPGACICRGNGYCGSGSD
    

Molecular Weight3362.80 Da

Isoelectric Point (pI)7.77

Net Charge (pH 7.0)0.71

Net Charge (pH 7.4) 0.41

Charge Density (pH 7.0) 0.0207

GRAVY Index-0.11

Hydrophobic Moment 0.53

Boman Index-0.02

Instability Index61.78

Aliphatic Index 51.76

Aromaticity 0.0294

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1453.67

LogP -22.59

H-bond Donors 57.0

H-bond Acceptors 53.0

Rotatable Bonds 107.0

Heavy Atoms 229.0

Ring Count 3.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023410 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAlexa-488

C-TermCyclization

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

TargetRAW 264.7 cells; MCF-7 cells

MethodFluorescence/confocal cellular uptake assay

RECORD: Rec_0041737 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCyclotide/MCoTI

Tax ID3674

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermFluorophore labeling

C-TermCyclization

Disulfide4-21, 11-23, 17-29

Other ModsN-term detail: Lysine rsidue labeled with Alexa-488; backbone cyclization reported in source

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

TargetRAW 264.7 cells; MCF-7 cells

MethodFluorescence/confocal cellular uptake assay

RECORD: Rec_0178940 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermLysine rsidue labeled with Alexa-488

C-TermCyclization

Bio-Activity Profile

Function

Drug Delivery Vehicle Cell-penetrating peptide

RECORD: Rec_0196787 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMCoKKAA

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAlexa Fluor conjugation

C-TermCyclization

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery

TargetRAW 264.7 cells; MCF-7 cells

MethodFluorescence/confocal cellular uptake assay