Peptide Database

Peptide NameSLAY-screened peptide P257

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC89H145N23O30S4

DescriptionStandard

        KCCSPDTCPTVPEIHMPLSS
    

Molecular Weight2145.50 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-1.18

Net Charge (pH 7.4) -1.48

Charge Density (pH 7.0) -0.0590

GRAVY Index-0.12

Hydrophobic Moment 0.27

Boman Index0.07

Instability Index95.53

Aliphatic Index 53.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 811.51

LogP -9.90

H-bond Donors 29.0

H-bond Acceptors 34.0

Rotatable Bonds 62.0

Heavy Atoms 146.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0297726 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/