Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length397 amino acids

Chemical FormulaC1983H3178N534O585S20

DescriptionStandard

        MDGISISISLNLGKDQSGHPTVSVTHCSNSIGQVSIHISGSLSWIINLFHQRIEKNIKKILEQKICEMVRKSAASNLTPYLQSLPVTTTIDQISGIDYRLVENPQVSSEDLNVFFKGEFFSQSQRSPVPFDAPALMLPQQYDHMVYFAVSEYVFNTASRVYYQAGRMNVTITNEHLKRLTTLAAKDSAKKWRKQNGKPNCMNSGSTPLTTMLLCYSSNFLLPLLQGPLNLPMQLNTNMLQALVPQLSRLHRNMQVELEASPESEPLLMFTPGNVTLTPVMNIQAVALLPNSTERKPLFQFRVKTNVSISIRMNSSRIVGSVTEASKLELELNHSSVSYINMPLMNAILNYYVLNTIYPSLNAKLEEGLPLPLPRDTFLKNMDLQVHKNFLLLGADIN
    

Molecular Weight44500.97 Da

Isoelectric Point (pI)8.89

Net Charge (pH 7.0)5.28

Net Charge (pH 7.4) 4.46

Charge Density (pH 7.0) 0.0133

GRAVY Index-0.11

Hydrophobic Moment 0.86

Boman Index0.07

Instability Index40.55

Aliphatic Index 98.19

Aromaticity 0.0705

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025558 VERIFIED: NO

Provenance & Taxonomy

OrganismDipodomys ordii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria