Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length180 amino acids

Chemical FormulaC892H1422N246O243S7

DescriptionStandard

        PTTPPMAQEPTLLLAVTEFVANSAAFTYFTAGALARNISSDMLPRRFPLQLSTKSMGVFSPQLQELYPDQPMELRLWARQQPLLSCHPDALHGTLLSSAEAFVVLPNATRVPAFLLHIDANVTGKPTITRNRLGGTVRLTGRAQGLPVPQVKRLETLLKFGLWLFGVPRANSKCCPHPVP
    

Molecular Weight19704.79 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)7.29

Net Charge (pH 7.4) 6.96

Charge Density (pH 7.0) 0.0405

GRAVY Index0.03

Hydrophobic Moment 0.54

Boman Index0.10

Instability Index54.58

Aliphatic Index 93.78

Aromaticity 0.0722

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7675.98

LogP -87.01

H-bond Donors 264.0

H-bond Acceptors 261.0

Rotatable Bonds 619.0

Heavy Atoms 1388.0

Ring Count 39.0

Amide Bonds 194.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0276423 VERIFIED: NO

Provenance & Taxonomy

OrganismCalcarius ornatus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria