Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length178 amino acids

Chemical FormulaC891H1351N201O274S8

DescriptionStandard

        EIDYSLNSLPAVSQPYIDLDLKGIVYPGGNYTAPPFVAAPFTVPDQSDSMLYLAISEYFFQTSSFAYYTAGAFNITIAEETCSYFNISSEIFGSIIPEVAQYSVTPYPVMLKLMATETPIISLQQDSFALEIQGSMEVFAVLPDSTTQSLFTMNIAANTSIAVNIFDQKLMGSLCLNR
    

Molecular Weight19518.96 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-13.17

Net Charge (pH 7.4) -13.40

Charge Density (pH 7.0) -0.0740

GRAVY Index0.30

Hydrophobic Moment 0.49

Boman Index0.26

Instability Index53.21

Aliphatic Index 93.20

Aromaticity 0.1292

Extinction Coeff. Reduced 16390.00

Extinction Coeff. Oxidized 16515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7505.25

LogP -78.20

H-bond Donors 253.0

H-bond Acceptors 269.0

Rotatable Bonds 616.0

Heavy Atoms 1374.0

Ring Count 35.0

Amide Bonds 194.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366229 VERIFIED: NO

Provenance & Taxonomy

OrganismCasuarius casuarius (Southern cassowary) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria