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MYP_002149
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Basic Information
Casein beta [158-175]
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
18 amino acids
C86H146N22O26
Standard
Sequence
PPQSVLSLSQSKVLPVPQ
Physicochemical Analysis
1904.21 Da
9.18
0.96
0.90
0.0532
0.00
0.29
0.12
128.45
113.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
753.87
-8.42
24.0
27.0
58.0
134.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025806 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
25 μM
IC50
RECORD: Rec_0259808 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
25 μM
IC50
PaperAntihypertensive Effect of the Peptides Derived from Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790 | Yamamoto, N. et al. | DOI: 10.3168/jds.S0022-0302(94)77026-0 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0300304 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 27.8%, T 50.0%, C 22.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0367351 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
25000 μM
IC50
PaperAntihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. PMID8201050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8201050/
RECORD: Rec_0416867 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PMID8201050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8201050/