Peptide Database

Peptide NameSLAY-screened peptide P5538

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC89H139N29O21

DescriptionStandard

        SPLPRNTHHIPWLINR
    

Molecular Weight1951.24 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)1.63

Net Charge (pH 7.4) 1.33

Charge Density (pH 7.0) 0.1022

GRAVY Index-0.81

Hydrophobic Moment 0.46

Boman Index-0.10

Instability Index78.14

Aliphatic Index 97.50

Aromaticity 0.0625

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 797.04

LogP -6.32

H-bond Donors 27.0

H-bond Acceptors 25.0

Rotatable Bonds 56.0

Heavy Atoms 139.0

Ring Count 7.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0163240 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/