Peptide Database

Peptide NameSLAY-screened peptide P2200

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC98H146N34O28

DescriptionStandard

        LQSNRHGHPTHANSFTHPPI
    

Molecular Weight2248.42 Da

Isoelectric Point (pI)9.78

Net Charge (pH 7.0)1.11

Net Charge (pH 7.4) 0.70

Charge Density (pH 7.0) 0.0554

GRAVY Index-1.16

Hydrophobic Moment 0.25

Boman Index-0.10

Instability Index58.97

Aliphatic Index 44.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 976.66

LogP -13.00

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 65.0

Heavy Atoms 160.0

Ring Count 8.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0356487 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/