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MYP_002070
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Basic Information
Lycotoxin I
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuroactive peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C135H223N37O30
Standard
Sequence
IWLTALKFLGKHAAKHLAKQQLSKL
Physicochemical Analysis
2844.44 Da
10.60
4.93
4.62
0.1972
0.06
0.58
0.10
21.51
125.20
0.0800
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1091.61
-5.49
38.0
37.0
99.0
202.0
5.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0186474 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans clinical isolate
PMID9442044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
RECORD: Rec_0202908 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
278031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
35.2 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0210865 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Insecticidal
Pseudomonas aeruginosa
6.25 μM
MIC
PaperLycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.
RECORD: Rec_0257466 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli DH5
80-150 μM
MIC
PMID9442044;18098329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
RECORD: Rec_0272853 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans clinical isolate
100-200 μM
MIC
PMID9442044;18098329 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
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