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MYP_002070
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Basic Information
Lycotoxin I
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuroactive peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C135H223N37O30
Standard
Sequence
IWLTALKFLGKHAAKHLAKQQLSKL
Physicochemical Analysis
2844.44 Da
10.60
4.93
4.62
0.1972
0.06
0.58
0.10
21.51
125.20
0.0800
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1091.61
-5.49
38.0
37.0
99.0
202.0
5.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099380 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Neuroactive
Rabbit erythrocytes
200 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/9442044/ PMID9442044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
RECORD: Rec_0102500 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperY.Lizhen, M.E.Adams. "Lycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis."The Journal of Biological Chemistry, vol.273,No.4:2059-2066.
RECORD: Rec_0113492 VERIFIED: NO
Provenance & Taxonomy
Wolf spider [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0118552 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Insecticidal
not hemo.lytic
125 μM
MIC
PaperLycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.
RECORD: Rec_0120308 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Insecticidal
Bacillus subtilis
6.25 μM
MIC
PaperLycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.
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