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MYP_002070
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Basic Information
Lycotoxin I
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Insecticidal/Pest control ▸ Insecticidal activity
Neurological / Signaling ▸ Neuroactive peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
25 amino acids
C135H223N37O30
Standard
Sequence
IWLTALKFLGKHAAKHLAKQQLSKL
Physicochemical Analysis
2844.44 Da
10.60
4.93
4.62
0.1972
0.06
0.58
0.10
21.51
125.20
0.0800
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1091.61
-5.49
38.0
37.0
99.0
202.0
5.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001113 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Insecticidal
Escherichia coli
25 μM
MIC
PaperLycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.
RECORD: Rec_0049247 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 48.0%, E 0.0%, T 40.0%, C 12.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Toxic Antimicrobial Cytotoxic
PaperIn silico approach for predicting toxicity of peptides and proteins PMID24058508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24058508/
RECORD: Rec_0070948 VERIFIED: NO
Provenance & Taxonomy
Lycosa carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Insecticidal
PaperPatent US 8334366 B1 Evidence URLhttps://patents.google.com/patent/US8334366B1/en PatentUS 8334366 B1
RECORD: Rec_0077544 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Insecticidal
Escherichia coli D31
10-20 μM
MIC
PaperLycotoxins, Antimicrobial Peptides from Venom of the Wolf Spider Lycosa carolinensis.
RECORD: Rec_0096350 VERIFIED: YES
Provenance & Taxonomy
Hogna carolinensis [Animal]
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida glabrata.B. thuringiensis subsp. Israelensis
PMID9442044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9442044/
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