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MYP_002032
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Basic Information
pTAT(48–60)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Delivery / Targeting ▸ Targeting ligand ▸ Targeting
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C70H131N35O16
Standard
Sequence
GRKKRRQRRRPPQ
Physicochemical Analysis
1719.01 Da
12.00
7.76
7.55
0.5968
-3.49
0.48
-1.47
225.75
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
904.56
-11.77
34.0
24.0
61.0
121.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0282585 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: 4-(10,15,20-Tri-4-pyridinyl-21H,23H-porphin-5-yl)benzaldehyde
Bio-Activity Profile
Anticancer
PaperSyntheses and cellular studies of water soluble porphyrin-peptide conjugates. Proceedings of SPIE-The International Society for Optical Engineering. 2008 Evidence URLhttps://doi.org/10.1117/12.698445
RECORD: Rec_0291737 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cys addition for conjugation
None
N-term detail: Cys added to N -terminus for conjugation of report
Bio-Activity Profile
Cell-penetrating peptide
HeLa; HCT116; HL-60; K562; Molt4; NIH-3T3; primary hepatocyte cultures
Cellular uptake assay
PMID15859953 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15859953/
RECORD: Rec_0303709 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: Porphine derivative
Bio-Activity Profile
Anticancer
PaperPeptide-Mediated Cell Transport of Water Soluble Porphyrin Conjugates. Journal of Medicinal Chemistry. 2006 Evidence URLhttps://doi.org/10.1021/jm050893b
RECORD: Rec_0309354 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Fluorescein/FITC labeling
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperTranslocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins PMID25016968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25016968/
RECORD: Rec_0324285 VERIFIED: YES
Provenance & Taxonomy
HIV-1 [Virus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa
128 μM
MIC
PMID33981626 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33981626/
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