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MYP_002032
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Basic Information
pTAT(48–60)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Delivery / Targeting ▸ Targeting ligand ▸ Targeting
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C70H131N35O16
Standard
Sequence
GRKKRRQRRRPPQ
Physicochemical Analysis
1719.01 Da
12.00
7.76
7.55
0.5968
-3.49
0.48
-1.47
225.75
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
904.56
-11.77
34.0
24.0
61.0
121.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0207529 VERIFIED: YES
Provenance & Taxonomy
HIV-1 [Virus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
128 μM
MIC
PMID33981626 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33981626/
RECORD: Rec_0220261 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Maleimide addition
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperTranslocation of cell-penetrating peptides across the plasma membrane is controlled by cholesterol and microenvironment created by membranous proteins PMID25016968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25016968/
RECORD: Rec_0239837 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
Synthetic CPP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Maleimide labeling
Amidation
N-term detail: Maleimide
Bio-Activity Profile
Cell-penetrating peptide
9 L/LacZ cells
Cellular uptake assay
Evidence URLhttps://patents.google.com/patent/US20060035815 PatentUS20060035815
RECORD: Rec_0254832 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID23585561 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23585561/
RECORD: Rec_0264106 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Fluorescein/FITC labeling
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PaperA truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus PMID9188504 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9188504/
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