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MYP_002013
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Basic Information
Brevinin-1JDa (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
24 amino acids
C119H198N30O28S2
Standard
Sequence
FLPAVIRVAANVLPTVFCAISKKC
Physicochemical Analysis
2561.16 Da
9.50
2.74
2.50
0.1141
1.28
0.58
0.35
33.66
130.00
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
912.53
-5.44
33.0
33.0
79.0
179.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0101122 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Odorrana jingdongensis [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus MRSA
6-13 μM
MIC
PaperAntimicrobial peptides from the skin of the Asian frog, Odorrana jingdongensis: De novo sequencing and analysis of tandem mass spectrometry data
RECORD: Rec_0119211 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Rabbit erythrocytes 79.26.8% lysis
128 μg/mL
Hemolysis
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0128064 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
16 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0157089 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
16 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0171173 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Escherichia coli
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
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