Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2413H3813N611O682S17

DescriptionStandard

        MARGPDSTLRWATLVVLAALGTAVTASPNPGVVARITQKGLDYACQQGVMILQKELEKITIPPFSGSFKVKYLGKGQYSFYSMVIRGFKLPSSQIRPSPNQGLDLSIKDASIKISGKWKAQKNFIKAKGDFDLSVEGISISAGLKLGYDPASGHSTVACSSCNSHINSVRVHISGSSVGWLIQLFHKKIESSLQNTMNSKICEVVTSTVSSKLQPYFETLPVTVKLDNVAGIDYSLVAPPKAMADNLDVHLKGEVFSLAHRSPSPFAPPVLNLPTDHDLMVYLGISEYFFNTAGLVYQEAGVLNLTLKDDMIPKESKFHLTTNFFGTLIPQVAKMFPNMEVQLLIWASVPPHLTVCPTGLDIIFALETQAFAVLPNSSLAPLFLLEMNTNVSVDVGARSDRLVGELKLNKLLLNLKHSDIGPFSVELLQMVMNYVLPTVVLPEINEKLQKGFPLPLPAYIQLFNLVLQPHQDFLLFGADVHYS
    

Molecular Weight52839.88 Da

Isoelectric Point (pI)8.12

Net Charge (pH 7.0)2.52

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.0052

GRAVY Index0.16

Hydrophobic Moment 0.65

Boman Index0.17

Instability Index37.56

Aliphatic Index 104.31

Aromaticity 0.0849

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41620.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040077 VERIFIED: NO

Provenance & Taxonomy

OrganismVicugna pacos (Alpaca) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria