Peptide Database

Peptide Nameneuregulin-2

Function Ontology

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length293 amino acids

Chemical FormulaC1433H2305N413O427S14

DescriptionStandard

        CYSPSLKSVQDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVISVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQK
    

Molecular Weight32600.05 Da

Isoelectric Point (pI)9.49

Net Charge (pH 7.0)19.75

Net Charge (pH 7.4) 19.22

Charge Density (pH 7.0) 0.0674

GRAVY Index-0.60

Hydrophobic Moment 0.75

Boman Index-0.13

Instability Index42.44

Aliphatic Index 72.15

Aromaticity 0.0785

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 35130.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0239338 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residuest at positions 36, 167 and 235. Predicted disulphide bond formation between cysteine resdiues at positions 146 and 200, 234 and 248, 242 and 259, and 261 and 270

Bio-Activity Profile

Function

Signaling peptide

Targeterb-b2 receptor tyrosine kinase 3 (Human); erb-b2 receptor tyrosine kinase 4 (Human)