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MYP_001777
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Basic Information
Uperin 3.5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C80H145N23O22
Standard
Sequence
GVGDLIRKAVSVIKNIV
Physicochemical Analysis
1781.15 Da
9.99
1.76
1.55
0.1035
0.88
0.78
0.22
20.28
165.88
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
743.48
-5.89
26.0
24.0
62.0
125.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0186981 VERIFIED: YES
Provenance & Taxonomy
Uperoleia mjobergii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Non-hemolytic
S. epidermidis (Gram-positive)
PMID26676975;31385514;33431675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26676975/
RECORD: Rec_0201585 VERIFIED: YES
Provenance & Taxonomy
Floodplain toadlet [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis
12.5 μg/mL
MIC
PaperNovel uperin peptides from the dorsal glands of the australian floodplain toadlet Uperoleia inundata.
RECORD: Rec_0214461 VERIFIED: YES
Provenance & Taxonomy
Uperoleia mjobergii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Non-hemolytic
L. innocua (Gram-positive)
PMID26676975;31385514;33431675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26676975/
RECORD: Rec_0232552 VERIFIED: NO
Provenance & Taxonomy
Floodplain toadlet [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0249726 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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