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MYP_001777
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Basic Information
Uperin 3.5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C80H145N23O22
Standard
Sequence
GVGDLIRKAVSVIKNIV
Physicochemical Analysis
1781.15 Da
9.99
1.76
1.55
0.1035
0.88
0.78
0.22
20.28
165.88
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
743.48
-5.89
26.0
24.0
62.0
125.0
0.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0112579 VERIFIED: YES
Provenance & Taxonomy
Uperoleia mjobergii [Animal]
Uperin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Leuconostoc lactis
3
MIC
PMID10461748 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10461748/
RECORD: Rec_0149924 VERIFIED: YES
Provenance & Taxonomy
Floodplain toadlet [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Streptococcus uberis
12.5 μg/mL
MIC
PaperNovel uperin peptides from the dorsal glands of the australian floodplain toadlet Uperoleia inundata.
RECORD: Rec_0164687 VERIFIED: YES
Provenance & Taxonomy
Uperoleia mjobergii [Animal]
Uperin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/P82042/entry
RECORD: Rec_0172760 VERIFIED: YES
Provenance & Taxonomy
Uperoleia mjobergii [Animal]
Uperin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
50 μg/mL
MIC
PMID10461748 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10461748/
RECORD: Rec_0185004 VERIFIED: YES
Provenance & Taxonomy
Uperoleia mjobergii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Anti-Gram-positive Non-hemolytic
L. lactis (Gram-positive)
PMID26676975;31385514;33431675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26676975/
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