Peptide Database

Peptide NameProkineticin-1

Function Ontology

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length86 amino acids

Chemical FormulaC410H650N130O117S10

DescriptionStandard

        AVITGACERDVQCGAGTCCAISLWLRGLRLCTPLGREGEECHPGSHKIPFFRKRQHHTCPCSPSLLCSRFPDGRYRCSQDLKNVNF
    

Molecular Weight9593.00 Da

Isoelectric Point (pI)8.79

Net Charge (pH 7.0)5.06

Net Charge (pH 7.4) 4.50

Charge Density (pH 7.0) 0.0588

GRAVY Index-0.35

Hydrophobic Moment 0.75

Boman Index-0.10

Instability Index53.16

Aliphatic Index 64.65

Aromaticity 0.0698

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3948.83

LogP -45.28

H-bond Donors 149.0

H-bond Acceptors 136.0

Rotatable Bonds 309.0

Heavy Atoms 667.0

Ring Count 17.0

Amide Bonds 90.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0036839 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyProkineticin

Tax ID10116

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Cardiovascular Growth regulation Development regulation ACE inhibitory

Targetcontracts gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0371018 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyProkineticin

Tax ID10116

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Cardiovascular Growth regulation Development regulation ACE inhibitory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0406362 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyProkineticin

Tax ID10116

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-19; 13-31; 18-59; 41-67; 61-77

Bio-Activity Profile

Function

Cardiovascular Growth regulation Development regulation ACE inhibitory

Targetcapillary endothelial cells derived from endocrine gland

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour