Peptide Database

Peptide NameToxin, k-HfTx1

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antifungal

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC105H159N37O37S4

DescriptionStandard

        GHACYRNCWREGNDEETCKERC
    

Molecular Weight2659.87 Da

Isoelectric Point (pI)5.59

Net Charge (pH 7.0)-1.18

Net Charge (pH 7.4) -1.50

Charge Density (pH 7.0) -0.0537

GRAVY Index-1.68

Hydrophobic Moment 0.64

Boman Index-0.51

Instability Index47.85

Aliphatic Index 4.55

Aromaticity 0.0909

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1243.75

LogP -15.80

H-bond Donors 48.0

H-bond Acceptors 41.0

Rotatable Bonds 88.0

Heavy Atoms 183.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0080955 VERIFIED: NO

Provenance & Taxonomy

OrganismHeterometrus fulvipes [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-22; 8-18

Bio-Activity Profile

Function

Toxin

TargetKv1

RECORD: Rec_0194125 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 50.0%, E 0.0%, T 27.3%, C 22.7% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic

RECORD: Rec_0303833 VERIFIED: YES

Provenance & Taxonomy

OrganismHeterometrus fulvipes [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetFusarium culmorum

Activity50 μg/mL

MethodMIC50

RECORD: Rec_0376913 VERIFIED: YES

Provenance & Taxonomy

OrganismHeterometrus fulvipes [Animal]

FamilyPotassium channel inhibitor kappa-KTx family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide4-22; 8-18

Bio-Activity Profile

Function

Toxin Venom Potassium channel inhibitor kappa-KTx family Pathogenesis-associated