Peptide Database

Peptide NameSLAY-screened peptide P2663

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H145N23O27S

DescriptionStandard

        DAYGFPAPYAPLGLCTFHQL
    

Molecular Weight2181.47 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0582

GRAVY Index0.29

Hydrophobic Moment 0.27

Boman Index0.37

Instability Index78.08

Aliphatic Index 73.50

Aromaticity 0.2000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 759.61

LogP -4.01

H-bond Donors 25.0

H-bond Acceptors 28.0

Rotatable Bonds 59.0

Heavy Atoms 155.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0397473 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/