Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length470 amino acids

Chemical FormulaC2413H3745N609O680S14

DescriptionStandard

        MLKCWCFFLLLHWLIQQLDANPGLKVRITQKGLDYGKEIGLKVLKQRIKDEKFPDWSGREKSGVGDVDYILSGVRINTIEFPDASVSLIPGSGIKLSTQHAYATFNANWSIRTWLFKDSGRGTVSISGVFITAVFTMSQDNTGHPSMSLDSCQMSIRGMDIKLNGTISWLYKFFIKYLEKPIHRSLHTHSCPNIRQGIQRIDAQLRALQVPTQIDAFAQIDYSLVNSPGIFQSYIDLDLKGAVYPFRNWSDLAFVPAPFTLPDKSNSMLYLGISEYFFKSASLAYYKAGAFNITTIEELSSYFNVTTKTFGNIIPEIAQYYVEAQPAMLNLMATAAPVVSLQPNAFSLEIHASMEVLVVQPNSTTQSIFTVNIIANTNASLTIFEQKLVGSLCLNRFQLFLADSSVGFFEVSLLENFLSYVLRNGVIPAANVILKKGFPLPNLDHITLLRPVIKINEGYLLISTDIDYNL
    

Molecular Weight52615.13 Da

Isoelectric Point (pI)7.63

Net Charge (pH 7.0)1.18

Net Charge (pH 7.4) 0.38

Charge Density (pH 7.0) 0.0025

GRAVY Index0.13

Hydrophobic Moment 0.78

Boman Index0.16

Instability Index35.64

Aliphatic Index 102.49

Aromaticity 0.1149

Extinction Coeff. Reduced 65320.00

Extinction Coeff. Oxidized 65570.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325347 VERIFIED: NO

Provenance & Taxonomy

OrganismPelodiscus sinensis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence