Peptide Database

Peptide Namecherimolacyclopeptide A

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC38H65N9O11S

DescriptionStandard

        PQTGMLPI
    

Molecular Weight856.04 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.04

Net Charge (pH 7.4) -0.10

Charge Density (pH 7.0) -0.0052

GRAVY Index0.30

Hydrophobic Moment 0.20

Boman Index0.36

Instability Index46.29

Aliphatic Index 97.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 307.56

LogP -2.15

H-bond Donors 10.0

H-bond Acceptors 12.0

Rotatable Bonds 25.0

Heavy Atoms 59.0

Ring Count 2.0

Amide Bonds 8.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0014719 VERIFIED: YES

Provenance & Taxonomy

OrganismAnnona cherimola [Plant]

FamilyOrbitide

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Cytotoxic

TargetTumoral KB cells

Activity0.6 μM

MethodIC50

RECORD: Rec_0128054 VERIFIED: YES