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MYP_001403
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Basic Information
Tigerinin 3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
12 amino acids
C66H103N15O15S2
Standard
Sequence
RVCYAIPLPICY
Physicochemical Analysis
1410.75 Da
8.05
0.74
0.50
0.0615
1.12
0.37
0.36
42.55
130.00
0.1667
2980.00
3105.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
468.20
-0.42
18.0
18.0
38.0
98.0
4.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050207 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
3-11
It contains one disulfide bond
Bio-Activity Profile
Antimicrobial Antifungal
yeast Saccharomyces cerevisiae ATCC 8530
80 μg/mL
MIC
PaperTigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
RECORD: Rec_0073835 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0079440 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus ATCC 8530
30 μg/mL
MIC
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0087450 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
rat erythrocytes
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0101829 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Tigerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antifungal
PaperK.P. Sai et al. / The Journal of Biological Chemistry 276 (2001) 2701-2707. Tigerinins: Novel Antimicrobial Peptides from the Indian Frog Rana tigerina Evidence URLhttps://www.uniprot.org/uniprotkb/P82653/entry
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