Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length508 amino acids

Chemical FormulaC2592H4031N647O741S19

DescriptionStandard

        MCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIDYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERRDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVMATEPPVISLLPGNFTLDIPASIMILTQPENSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRGNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP
    

Molecular Weight56721.86 Da

Isoelectric Point (pI)5.85

Net Charge (pH 7.0)-6.62

Net Charge (pH 7.4) -7.54

Charge Density (pH 7.0) -0.0130

GRAVY Index0.10

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index37.27

Aliphatic Index 100.39

Aromaticity 0.1063

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0150323 VERIFIED: NO

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyBPI/LBP

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence