Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2376H3702N610O674S17

DescriptionStandard

        MDFAYRLTLLFSIAAFVGTADAENPGLVVRVTQKGLDYALQEGVIALQQQLSHIQLKDIPGTHNHEIVGKVHYNIFSMNLGNFQLPGFQVSPIPNVGLKLSTSGGFFEVNGRWDVQHSFVHENGTFNIKVGGLGMSVGLNLRNIEHGKPTVSVADCSCHIANVEVHMSGTIGWLVKLFHDAVESKIRQELEDKICPEINDIINSKLSSLLQTLPVETNLDHISALDYSLMGPPSVMANWVDVFLKGEFFYRSHRTAPPFAPPAMSLPPEQDHMVYFAVSDYVFNTALLAYQSARALVLTLTDKMIPKEFGVHLNTNLLERVIPAVSKMYPNMPMKLKISAASTPALNITPGGVTLSPIGNFQAYAILPNSSLAPLFLLEVKTNAFAKAAVNSGKIVGTLENGKVEVSLSHSDVGPFSVSEINMAMNLLVPVILPHINDYLKYGFPLPLIEHIQLSDIVIKTYEHYLLFGANAHYE
    

Molecular Weight52141.60 Da

Isoelectric Point (pI)6.01

Net Charge (pH 7.0)-8.82

Net Charge (pH 7.4) -10.15

Charge Density (pH 7.0) -0.0186

GRAVY Index0.15

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index43.58

Aliphatic Index 103.41

Aromaticity 0.0884

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 38975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0107668 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis (Western clawed frog) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria