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MYP_001220
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Basic Information
KKK
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
7 amino acids
C40H67N11O8S
Standard
Sequence
KAWKMAK
Physicochemical Analysis
862.09 Da
10.30
2.76
2.55
0.3939
-1.01
0.63
-0.26
72.77
28.57
0.1429
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
331.77
-0.79
12.0
12.0
30.0
60.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0294982 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis
6.3 μg/mL
MIC
PaperHuy X Luong, Do-Hee Kim, Ngoan T Mai, Bong-Jin Lee, Young-Woo Kim. Mono-substitution effects on antimicrobial activity of stapled heptapeptides. Arch Pharm Res. 2017 Jun;40(6):713-719. Epub 2017 May 25. PMID28547390 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28547390/
RECORD: Rec_0324610 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Salmonella typhimurium ATCC 14028
50 μM
MIC
PaperHuy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Effects of lysine-to-arginine substitution on antimicrobial activity of cationic stapled heptapeptides. Arch Pharm Res. 2018 Nov;41(11):1092-1097. Epub 2018 Oct 25. PMID30361948 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30361948/
RECORD: Rec_0391235 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The J (position: 5) in sequence is norleucine. The Ⓧ (position: 2 and 6) indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 6633
12.5 μM
MIC
PaperHuy X Luong, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Effects of lysine-to-arginine substitution on antimicrobial activity of cationic stapled heptapeptides. Arch Pharm Res. 2018 Nov;41(11):1092-1097. Epub 2018 Oct 25. PMID30361948 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30361948/
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