Peptide Database

Peptide NameSLAY-screened peptide P375

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC88H144N24O34S4

DescriptionStandard

        IICLELANDDLCCKCHSSDD
    

Molecular Weight2210.49 Da

Isoelectric Point (pI)4.19

Net Charge (pH 7.0)-4.18

Net Charge (pH 7.4) -4.50

Charge Density (pH 7.0) -0.2091

GRAVY Index0.12

Hydrophobic Moment 0.26

Boman Index0.02

Instability Index45.06

Aliphatic Index 102.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 940.97

LogP -10.70

H-bond Donors 35.0

H-bond Acceptors 35.0

Rotatable Bonds 74.0

Heavy Atoms 150.0

Ring Count 1.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0239686 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/