Peptide Database

Peptide NameSLAY-screened peptide P1195

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC69H100N14O23S3

DescriptionStandard

        VYVCTASDCFMSYT
    

Molecular Weight1589.81 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.29

Net Charge (pH 7.4) -1.53

Charge Density (pH 7.0) -0.0919

GRAVY Index0.77

Hydrophobic Moment 0.32

Boman Index0.31

Instability Index52.51

Aliphatic Index 48.57

Aromaticity 0.2143

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 600.30

LogP -5.99

H-bond Donors 24.0

H-bond Acceptors 25.0

Rotatable Bonds 46.0

Heavy Atoms 109.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009003 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/