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MYP_001028
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Basic Information
Peptide 1(lactoferrin 418-429)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
12 amino acids
C56H96N18O18S
Standard
Sequence
SKHSSLDCVLRP
Physicochemical Analysis
1341.54 Da
7.97
0.54
0.26
0.0448
-0.40
0.35
-0.19
51.03
89.17
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
589.22
-7.28
22.0
21.0
43.0
93.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0302445 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus (A/Roma-ISS/2/08 H1N1) | MDCK cells
0.000004±0.00000037 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperBovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. | Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F. | Pathog Glob Health. 2012 Mar;106(1):12-9. | DOI:10.1179/2047773212Y.0000000004 | PMID:22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
RECORD: Rec_0313746 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Defensin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
A/Parma/24/09 H1N1
3.1±0.37
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0314026 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H3N2 Replication inhibition
A/Parma0/5/06 H3N2 | MDCK cells
0.0000058±0.0000007 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0320583 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Parma/24/09 H1N1 | MDCK cells
0.0000031±0.00000012 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0399391 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Roma-ISS/02/08 H1N1 | MDCK cells
0.000004±0.00000037 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
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