Peptide Database

Peptide NameSLAY-screened peptide P1973

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC85H135N25O26

DescriptionStandard

        TVAHLFNITNIHTNNLT
    

Molecular Weight1923.13 Da

Isoelectric Point (pI)6.61

Net Charge (pH 7.0)-0.43

Net Charge (pH 7.4) -0.72

Charge Density (pH 7.0) -0.0251

GRAVY Index0.13

Hydrophobic Moment 0.27

Boman Index0.21

Instability Index41.25

Aliphatic Index 114.71

Aromaticity 0.0588

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 839.56

LogP -9.79

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 60.0

Heavy Atoms 136.0

Ring Count 3.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0225977 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/