MYP_000913
Pegloticase
Immunology
▸
Immunomodulation
▸
Immunogen
Therapeutic / Biomedical activity
▸
Enzyme replacement therapy
Standard
298 amino acids
C1549H2430N408O448S8
Standard
TYKKNDEVEFVRTGYGKDMIKVLHIQRDGKYHSIKEVATTVQLTLSSKKDYLHGDNSDVIPTDTIKNTVNVLAKFKGIKSIETFAVTICEHFLSSFKHVIRAQVYVEEVPWKRFEKNGVKHVHAFIYTPTGTHFCEVEQIRNGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKDRCFATQVYCKWRYHQGRDVDFEATWDTVRSIVLQKFAGPYDKGEYSPSVQKTLYDIQVLTLGQVPEIEDMEISLPNIHYLNIDMSKMGLINKEEVLLPLDNPYGKITGTVKRKLSSRL
34192.85 Da
8.64
4.35
3.43
0.0146
-0.39
0.70
-0.02
29.33
86.21
0.1007
35870.00
36120.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0194510
VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Enzyme
32630
Structure & Mods
linear peptide/protein therapeutic [Linear]
canonical L-amino-acid peptide [L]
PEGylation
Bio-Activity Profile
Enzyme replacement
Vaccine
Immunogen
Median: ~14 days
RECORD: Rec_0425044
VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
PEGylated uricase
9823
Structure & Mods
linear peptide/protein therapeutic [Linear]
noncanonical stereochemical or chemical modification [Modified]
PEGylation
Bio-Activity Profile
-
Median: ~14 d