Peptide Database

Peptide NameSLAY-screened peptide P1291

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC78H116N20O25S2

DescriptionStandard

        YLCIDNNTPYMHSIN
    

Molecular Weight1798.00 Da

Isoelectric Point (pI)5.08

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.44

Charge Density (pH 7.0) -0.0776

GRAVY Index-0.38

Hydrophobic Moment 0.30

Boman Index0.10

Instability Index71.15

Aliphatic Index 78.00

Aromaticity 0.1333

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 738.10

LogP -7.15

H-bond Donors 25.0

H-bond Acceptors 27.0

Rotatable Bonds 54.0

Heavy Atoms 125.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254034 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/