Peptide Database

Peptide NameHedyotide B2 (hB2; Uncyclotides; Plants)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC125H198N34O39S6

DescriptionStandard

        IQCGESCVWIPCISSAWGCSCKNKICSS
    

Molecular Weight2993.50 Da

Isoelectric Point (pI)7.77

Net Charge (pH 7.0)0.70

Net Charge (pH 7.4) 0.41

Charge Density (pH 7.0) 0.0251

GRAVY Index0.42

Hydrophobic Moment 0.31

Boman Index0.19

Instability Index43.49

Aliphatic Index 69.64

Aromaticity 0.0714

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1168.71

LogP -14.64

H-bond Donors 47.0

H-bond Acceptors 46.0

Rotatable Bonds 95.0

Heavy Atoms 204.0

Ring Count 5.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0154584 VERIFIED: YES

Provenance & Taxonomy

OrganismLeptopetalum biflorum [Plant]; Hedyotis biflora [Plant]

FamilyCyclotide

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Antibacterial Enzymatic-degradation Anti-Gram-positive

TargetStaphylococcus epidermidis

Activity>80 μM

MethodMIC

RECORD: Rec_0238041 VERIFIED: NO

Provenance & Taxonomy

OrganismHedyotis biflora [Plant]

FamilyCyclotide

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

RECORD: Rec_0325267 VERIFIED: YES

Provenance & Taxonomy

OrganismHedyotis biflora [Plant]

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetStreptococcus salivarius

Activity>80 μM

MethodMIC

RECORD: Rec_0362001 VERIFIED: YES

Provenance & Taxonomy

OrganismHedyotis biflora [Plant]

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli

Activity>80 μM

MethodMIC

RECORD: Rec_0377661 VERIFIED: YES

Provenance & Taxonomy

OrganismLeptopetalum biflorum [Plant]; Hedyotis biflora [Plant]

FamilyCyclotide

Structure & Mods

Configdisulfide-stabilized linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Antibacterial Enzymatic-degradation Anti-Gram-negative

TargetEscherichia coli

Activity>80 μM

MethodMIC

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