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MYP_000804
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Basic Information
Hedyotide B2 (hB2; Uncyclotides; Plants)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
28 amino acids
C125H198N34O39S6
Standard
Sequence
IQCGESCVWIPCISSAWGCSCKNKICSS
Physicochemical Analysis
2993.50 Da
7.77
0.70
0.41
0.0251
0.42
0.31
0.19
43.49
69.64
0.0714
11000.00
11375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1168.71
-14.64
47.0
46.0
95.0
204.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028622 VERIFIED: YES
Provenance & Taxonomy
Hedyotis biflora [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Streptococcus aureus
80 μM
MIC
PaperPubMed PMID: 21979955 PMID21979955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21979955/
RECORD: Rec_0038257 VERIFIED: YES
Provenance & Taxonomy
Leptopetalum biflorum [Plant],Hedyotis biflora [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Enzymatic-degradation Anti-Gram-positive
Streptococcus salivarius
80 μM
MIC
PMID21979955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21979955/
RECORD: Rec_0057381 VERIFIED: YES
Provenance & Taxonomy
Leptopetalum biflorum [Plant],Hedyotis biflora [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Enzymatic-degradation
and -negative bacteria and two other strains of bacteria/ Staphylococcus aureus
80 μM
MIC
PMID21979955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21979955/
RECORD: Rec_0134007 VERIFIED: YES
Provenance & Taxonomy
Hedyotis biflora [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus epidermidis
80 μM
MIC
PaperPubMed PMID: 21979955 PMID21979955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21979955/
RECORD: Rec_0138078 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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