Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length463 amino acids

Chemical FormulaC2287H3654N574O654S24

DescriptionStandard

        KMSPCCLLALLAVISLTLAASPGVKVKLTDKGIEYGKQIGMASLQQKLKTMKVPDLSGTEKVPPIGKVKYSLTGMTIVNLGLPKSALVLMPGTGVRLAITNAFINLHGNWRVRYFRFIQDRGSFDLAINGLTITADIAIKSDETGRPTVSTVNCVANVGSASIKFHGGARYMEYIEALNTMLYLKRLADVITDMNPHLKTFNVLAKVDQYAEIEYSMVTSPTISKSSIEFSLKGEFYNIGKHQEPPFSPTPFSLPPQDNNMLYIGVSSFTPNSAGFVYNNAGALSLYVTDDMIPPSSPIRLNTGTFGVFIPEIAKRFPGMMMKLLVKTVKEPTISLEPNNVTVQASGTVTAYAIQPNTTLSPLFVLNMEGSVSAQMNVTGVKLAGAITLNKIEMTLGTSYVGQFQVRMIFSDYLFPCLFIFIVSALIEKGFPLPTIGKMNLINTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight50424.49 Da

Isoelectric Point (pI)9.16

Net Charge (pH 7.0)9.09

Net Charge (pH 7.4) 8.52

Charge Density (pH 7.0) 0.0196

GRAVY Index0.21

Hydrophobic Moment 0.74

Boman Index0.18

Instability Index32.74

Aliphatic Index 98.73

Aromaticity 0.0864

Extinction Coeff. Reduced 29340.00

Extinction Coeff. Oxidized 29590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0161995 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence