Peptide Database

Peptide NameT1968(FIV envelope protein (729-761))

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC178H274N46O57S

DescriptionStandard

        NITLGEWYNQTKDLQQKFYEIIMDIEQNNVQGK
    

Molecular Weight4002.42 Da

Isoelectric Point (pI)4.51

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.0677

GRAVY Index-0.97

Hydrophobic Moment 0.59

Boman Index-0.10

Instability Index59.61

Aliphatic Index 79.70

Aromaticity 0.1212

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1743.60

LogP -15.75

H-bond Donors 56.0

H-bond Acceptors 56.0

Rotatable Bonds 139.0

Heavy Atoms 282.0

Ring Count 5.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335568 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1:inhibition of cell-cell fusion between CEM4/IIIb cells and MOLT4 cells

Activity2.473 μM

MethodEC50

RECORD: Rec_0402745 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-FIV Fusion inhibition

TargetFeline immunodeficiency virus (FIV) | FIV/CrFK cells; HeLa cells

Activity2.067 μM

MethodEC90

Half-LifeMammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h

PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/

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