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MYP_000734
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Basic Information
DFT531
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C64H118N14O16
Standard
Sequence
GLLSLLSLGLKLL
Physicochemical Analysis
1339.71 Da
8.75
0.76
0.55
0.0584
1.85
0.39
0.58
-3.83
240.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
479.00
-1.04
17.0
17.0
47.0
94.0
0.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035920 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0049669 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells [50% hemolysis at 7 microM]
7 μM
Hemolysis
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0092990 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus USA 300
0.8 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0163418 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is poorly similar (85.71%) to DFTamP1 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
P-aeruginosa PAO1
>25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
RECORD: Rec_0186612 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
APD analysis reveals that this sequence is poorly similar (85.71%) to DFTamP1 . L: 62%. Chemical modification: C-terminal amidation
Bio-Activity Profile
Antimicrobial
K-pneumonia ATCC 13883
>25 μM
MIC
PaperLow cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens PMID31209048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31209048/
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