Peptide Database

Peptide NameSLAY-screened peptide P5458

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H145N25O30S

DescriptionStandard

        AHFENCGSGWVYSPSNLYLI
    

Molecular Weight2257.48 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-1.13

Net Charge (pH 7.4) -1.38

Charge Density (pH 7.0) -0.0563

GRAVY Index0.07

Hydrophobic Moment 0.29

Boman Index0.29

Instability Index28.39

Aliphatic Index 78.00

Aromaticity 0.2000

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 876.53

LogP -7.46

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 66.0

Heavy Atoms 160.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0238244 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/