Peptide Database

Peptide NameSLAY-screened peptide P252

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC90H152N38O27

DescriptionStandard

        TGRGRHPHGTRTVRIATPNN
    

Molecular Weight2198.41 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.57

Net Charge (pH 7.4) 3.28

Charge Density (pH 7.0) 0.1786

GRAVY Index-1.41

Hydrophobic Moment 0.51

Boman Index-0.40

Instability Index-0.23

Aliphatic Index 39.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1070.70

LogP -16.50

H-bond Donors 39.0

H-bond Acceptors 33.0

Rotatable Bonds 68.0

Heavy Atoms 155.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0209710 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/