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MYP_000469
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
32 amino acids
C148H243N39O46S5
Standard
Sequence
WKSESLCTPGCVTGALQTCFLQTLTCNCKISK
Physicochemical Analysis
3465.07 Da
8.42
1.71
1.43
0.0534
0.19
0.35
0.10
38.42
73.12
0.0625
5500.00
5750.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1378.89
-16.74
53.0
53.0
113.0
238.0
4.0
34.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0066857 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PaperBACTIBASE second release: a database and tool platform for bacteriocin characterization PMID20105292 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20105292/
RECORD: Rec_0078650 VERIFIED: NO
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://www.uniprot.org/uniprotkb/P10946/entry
RECORD: Rec_0107089 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0161432 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
There are two di-dehydroalanines (Dha), S3, S31; one di-dehydrobutyrine (Dhb), T18; one lanthionine, S3-C7; and four methyllanthionines, T8-C11, T13-C19, T23-C26, and T25-C28 (provided by T. Stein). In addiiton, this peptide can be succinylated via Trp, leading to reduced activity (Chan et al., 1993)
Bio-Activity Profile
Antimicrobial
Bacillus cereus T spore outgrowth at a very low concentration of 80 nM. In addition, f vegetative Bacillus cereus was lysed at 8 ug/ml. spore is a dormant, reproductive cell whereas vegetative cell is any cell that does not produce gametes. MOA: The peptide antibiotic subtilin acts by formation of voltage-dependent multi-state pores in bacterial
PaperSubtilin, an antibiotic produced by Bacillus subtilis; action on various organisms.
RECORD: Rec_0251368 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Succinylation
None
There are two dehydroalanines (S5; S31),one dehydrobutyrine (T18),one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28)
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPubMed PMID: 4154277 | PubMed PMID: 21239550 PMID4154277;21239550 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4154277/
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