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MYP_000468
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Basic Information
HR2-8
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
46 amino acids
C243H385N63O74
Standard
Sequence
ISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPW
Physicochemical Analysis
5373.03 Da
4.77
-2.23
-2.45
-0.0485
-0.43
0.70
0.01
32.09
116.52
0.0870
13980.00
13980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2268.56
-17.95
75.0
72.0
184.0
380.0
7.0
53.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119595 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
HR2-derived fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
EC50
PaperSuppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein PMID15184046 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15184046/
RECORD: Rec_0167581 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Heptad repeat peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
SARS coronavirus (Virus entry); 293T
Luciferase assay
PaperSuppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. | Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H. | Biochem Biophys Res Commun. 2004 | PMID:15184046 PMID15184046 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15184046/
RECORD: Rec_0212408 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 56.5%, E 0.0%, T 6.5%, C 37.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/