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MYP_000428
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Basic Information
Linear Desmethoxymajusculamide C
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
9 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXGXGXXXA
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0028679 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Bio-Activity Profile
Antimicrobial Anticancer
N2a
1 μM
IC50
PaperPubMed PMID: 19489598 PMID19489598 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19489598/
RECORD: Rec_0038799 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Bio-Activity Profile
Antimicrobial Anticancer
HCT 116
0.016 μM
IC50
PaperPubMed PMID: 19489598 PMID19489598 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19489598/
RECORD: Rec_0051899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-435
0.23 μM
IC50
PaperPubMed PMID: 19489598 PMID19489598 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19489598/
RECORD: Rec_0060732 VERIFIED: YES
Provenance & Taxonomy
Lyngbya majuscula [Bacterium]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Bio-Activity Profile
Antimicrobial Anticancer
N2a
1 μM
IC50
PaperPubMed PMID: 19489598 PMID19489598 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19489598/
RECORD: Rec_0094987 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
X(1)=3-amino-2-methylpentanoic acid; X(2)=2-hydroxy-3-methylpentanoate; X(4)=METH-Ile; X(6)=METH-Val; X(7)=METH-Phe; X(8)=4-amino-2,2-dimethyl-3-oxo-pentanoate
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 19489598 PMID19489598 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19489598/
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